A. González-Pérez1 and L.A. García Rodríguez1
(1) Centro Español de Investigación Farmacoepidemiológica (CEIFE), C/Almirante 28 2°, 28004 Madrid, Spain
Received: 25 November 2004 Accepted: 29 March 2005
Abstract Objective: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK.
Methods: Population based case–control study nested in a cohort.
Results: We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59–0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50–0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73–1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas.
Conclusion: Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.
Keywords diabetes mellitus - epidemiologic studies - prostate cancer
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment