Tugba Yavuzsen1 , Ilhan Oztop1, Ugur Yilmaz1, Caner Cavdar2, Aykut Sifil2, Sulen Sarioglu3 and Mehmet Alakavuklar1
(1) Institute of Oncology, University of Dokuz Eylul, Balcova, 35340 Izmir, Turkey
(2) Department of Internal Medicine, Divison of Nephrology, University of Dokuz Eylul, Faculty of Medicine, Izmir, Turkey
(3) Department of Pathology, University of Dokuz Eylul, Faculty of Medicine, Izmir, Turkey
Received: 09 April 2003 Accepted: 19 August 2003
Abstract Malignant neoplasms are rarely associated with glomerular changes. The glomerular lesion seen most often in patients with malignancies is membranous glomerulonephritis. We report here a case of gastric cancer associated with rapidly progressive glomerulonephritis (RPGN). A 57-year-old man was admitted to our hospital with acute renal failure. Renal biopsy was performed, and the diagnosis was RPGN. Steroid treatment was instituted, but was complicated by hematemesis, and an early-stage gastric cancer was found after endoscopic examinations. Gastric biopsy revealed gastric adenocarcinoma. The patients renal function improved with corticosteroid treatment and hemodialysis, and total gastrectomy was performed. The improvement in renal function persisted after the removal of the gastric cancer, and the RPGN and cancer have been in remission for 3 years.
Key words Gastric cancer - Rapidly progressive glomerulonephritis
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