Formation of benzo[a]pyrene-DNA adducts in blood monocytes from lung cancer patients with a familial history of lung cancer

The in vitro formation of benzo[a]pyrene-DNA adducts was determined in peripheral blood monocytes of 22 lung cancer patients with at least one first-degree relative with lung cancer and compared to results obtained in 30 healthy controls. In patients, the mean (SEM) adduct formation was 2.8 (0.3) fmol/g DNA as compared to 2.1 (0.1) fmol/g in controls (pKey wordsLung cancer-Genetic predisposition-Familial cancer-Benzo[a]pyrene, DNA adductsThis work was supported by a grant from the German Minister for Research and Technology, BMFT